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Paradoxical role of Id proteins in regulating tumorigenic potential of lymphoid cells

Sumedha Roy, Yuan Zhuang

Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 374-386 doi: 10.1007/s11684-018-0652-x

Abstract: On the contrary, certain Id proteins are reported to act as tumor suppressors in the development of BurkittThe contexts and mechanisms by which Id proteins can serve in such contradictory roles to determine tumorWe re-examine the derailment of these regulatory mechanisms in lymphocytes that facilitate tumor development

Keywords： Id proteins lymphoma leukemia T cells B cells tumor suppressor oncogene

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ECRG4: a new potential target in precision medicine

Xin Qin, Ping Zhang

Frontiers of Medicine 2019, Volume 13, Issue 5, Pages 540-546 doi: 10.1007/s11684-018-0637-9

Abstract: Esophageal cancer-related gene-4 ( ), which is initially known as a new candidate tumor suppressor gene

Keywords： ECRG4 tumor suppressor gene sentinel molecule precision medicine cell senescence epithelium homeostasis

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Potential functions of esophageal cancer-related gene-4 in the cardiovascular system

Rui Zhou, Yuanshu Liu, Wenjun Huang, Xitong Dang

Frontiers of Medicine 2019, Volume 13, Issue 6, Pages 639-645 doi: 10.1007/s11684-019-0701-0

Abstract: during tumorigenesis, and expression levels are inversely correlated with the malignant phenotype of tumorcells, validating that is a real tumor suppressor gene.Unlike other tumor suppressor genes that usually encode membrane or intracellular proteins, encodesHere, we briefly review the latest discoveries on Ecrg4 and its underlying molecular mechanisms as a tumorsuppressor and focus on the emerging roles of Ecrg4 in the CVS.

Keywords： tumor suppressor gene esophageal cancer-related gene-4 cardiovascular disease hypoxia

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Expression of Syk in non-small cell lung cancer and its relationship with clinicopathological parameters

Fen LAN, Shengdao XIONG, Weining XIONG, Guopeng XU, Xiaoxia LU

Frontiers of Medicine 2009, Volume 3, Issue 1, Pages 41-44 doi: 10.1007/s11684-009-0009-6

Abstract: The positive rate of Syk was 46.15% (18/39) and 100% (39/39) in NSCLC and tumor-surrounding normal lungThe expression level of Syk in NSCLC was significantly lower than that in tumor-surrounding normal lungno significant association between Syk expression and lymph node metastasis, differentiation degree, tumorsize and tumor node metastasis (TNM).demonstrated that Syk was aberrantly expressed in the NSCLC and might have a significant impact on tumor

Keywords： Syk kinase carcinoma non-small-cell lung tumor suppressor protein p53

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Molecular characterization of two suppressor of cytokine signaling 1 genes (

Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 1, Pages 73-83 doi: 10.15302/J-FASE-2015044

Abstract: Suppressor of cytokine signaling 1 (SOCS1) protein can inhibit the signal transduction triggered by some

Keywords： chicken SOCS1a SOCS1b growth hormone prolactin

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Heterogeneity of the tumor immune microenvironment and clinical interventions

Frontiers of Medicine 2023, Volume 17, Issue 4, Pages 617-648 doi: 10.1007/s11684-023-1015-9

Abstract: Heterogeneity of the tumor immune microenvironment and clinical interventions

Keywords： Heterogeneity tumor immune

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Recent advances in myeloid-derived suppressor cell biology

Mahmoud Mohammad Yaseen, Nizar Mohammad Abuharfeil, Homa Darmani, Ammar Daoud

Frontiers of Medicine 2021, Volume 15, Issue 2, Pages 232-251 doi: 10.1007/s11684-020-0797-2

Abstract: In recent years, studying the role of myeloid-derived suppressor cells (MDSCs) in many pathological inflammatory

Keywords： non-human primates (rhesus macaques) myeloid-derived pro-inflammatory cells (MDPCs) autoimmune disorders alloimmune responses pregnancy mature MDSCs multiple sclerosis Yin-Yang law of MDSCs

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Proteins moonlighting in tumor metabolism and epigenetics

Lei Lv, Qunying Lei

Frontiers of Medicine 2021, Volume 15, Issue 3, Pages 383-403 doi: 10.1007/s11684-020-0818-1

Abstract: interplay of multiple signaling pathways and restrained by oxygen and nutrient accessibility in the tumorThe signal−moonlighting protein−metabolism axis facilitates the adaptation of tumor cells under varying

Keywords： moonlighting function tumor metabolism epigenetics

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Complex interplay between tumor microenvironment and cancer therapy

Minhong Shen, Yibin Kang

Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 426-439 doi: 10.1007/s11684-018-0663-7

Abstract:

Tumor microenvironment (TME) is comprised of cellular and non-cellular components that exist withinand around the tumor mass.Given the importance of TME in tumor progression and therapy resistance, strategies that remodel TME

Keywords： tumor microenvironment therapy response treatment resistance

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Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma

Frontiers of Medicine 2023, Volume 17, Issue 4, Pages 699-713 doi: 10.1007/s11684-022-0972-8

Abstract: However, the underlying mechanism of alterations in the tumor microenvironments resulting in CAR-T cellSingle-cell RNA sequencing results were obtained from core needle biopsy tumor samples collected fromM2-subtype macrophages were significantly involved in both in vivo and in vitro anti-tumorImmunosuppressive tumor microenvironments persisted before CAR-T cell therapy, during both cell expansionThus, our findings provided a clinical rationale for targeting tumor microenvironments and reprogramming

Keywords： anti-CD19 chimeric antigen receptor T immunotherapy diffuse large B cell lymphoma tumor microenvironment tumor-associated macrophage metabolism

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Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives

Bingxue Shang, Zhifei Cao, Quansheng Zhou

Frontiers of Medicine 2012, Volume 6, Issue 1, Pages 67-78 doi: 10.1007/s11684-012-0176-8

Abstract: Although the current antiangiogenic drugs reduce the density of tumor blood vessels and result in tumor, which fosters tumor cells to become more aggressive and metastatic.on the pioneering work on tumor blood vessels by several other researchers.roles in tumor neovascularization, growth, and metastasis.Therefore, multiple-targeting of vasculogenic tumor cells and genes may improve the efficacy of tumor

Keywords： angiogenesis vasculogenesis neovascularization tumor vasculature normalization traditional Chinese medicine

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Natural killer cell lines in tumor immunotherapy

Min Cheng, Jian Zhang, Wen Jiang, Yongyan Chen, Zhigang Tian

Frontiers of Medicine 2012, Volume 6, Issue 1, Pages 56-66 doi: 10.1007/s11684-012-0177-7

Abstract: genetically modifying NK cell lines by increasing their expression of cytokines and engineering chimeric tumorIn this review, NK cells in tumor immunotherapy are discussed, and a list of therapeutic NK cell lines

Keywords： natural killer cell natural killer cell line tumor immunotherapy genetic modification

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Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy

Kai Shi, Matthew Haynes, Leaf Huang

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4, Pages 676-684 doi: 10.1007/s11705-017-1640-4

Abstract: Specifically, reversing the immune-suppressive effects of the tumor microenvironment, mediated by a variety

Keywords： vaccine nanoparticle tumor immunotherapy microenvironment

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carmustine loaded natural extracellular matrix hydrogel for inhibition of glioblastoma recurrence after tumor

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 4, Pages 536-545 doi: 10.1007/s11705-021-2067-5

Abstract: recurrence after tumor resection, both free BCNU and BCNU- poly (lactic-co-glycolic acid) (the ratioThe hydrogel was injected into the resection cavity of a glioblastoma tumor immediately after tumor removalFree drugs were released instantly to kill the residual tumor cells, while drugs in nanoparticles werecontinuously released to achieve a continuous and effective inhibition of the residual tumor cells forThese combined actions effectively restricted tumor growth in rats.

Keywords： BCNU glioblastoma recurrence tumor resection nanoparticles hydrogel

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Bacteria-mediated tumor-targeted delivery of tumstatin (54-132) significantly suppresses tumor growth

Frontiers of Medicine 2022, Volume 16, Issue 6, Pages 873-882 doi: 10.1007/s11684-022-0925-2

Abstract: Tumor growth is an angiogenesis-dependent process and accompanied by the formation of hypoxic areas.Tumstatin is a tumor-specific angiogenesis inhibitor that suppresses the proliferation and induces theTreatment with VNP-Tum5 effectively suppressed tumor growth and prolonged survival in the mouse modelThis study is the first to use tumstatin-transformed VNP20009 as a tumor-targeted system for treatmentof melanoma by combining anti-tumor and anti-angiogenic effects.

Keywords： Salmonella VNP20009 tumstatin B16F10 melanoma apoptosis angiogenesis